VEGFA and cancer: Experimental studies of VEGF expression in breast cancer development will introduce the theme, in order to report important statements that support angiogenesis studies in cancer; secondly, the value of blood vessel density (BVD) assessment will be discussed because there is a significant correlation between high BVD and worse prognosis in many, but not all, cancers; also, there are disputable data related to the BVD meaning in breast cancer behaviour.