VEGFA and metastatic malignant neoplasm in the lymph nodes: In addition, lymph node metastasis group and distant metastasis group significantly overexpressed VEGF mRNA compared with negative control group, respectively, (9.99 ± 3.38-fold in lymph node metastasis group or 10.27 ± 5.90-fold in distant metastasis group versus 4.68 ± 1.28-fold in negative control group, resp., P < .05, Figure 3).