Furthermore, we analyzed the concomitant expression of HIF-1α and VEGF in colon cancer samples, demonstrating that 63% of colon cancer with lymph node involvement showed high expression of both HIF-1α and VEGF, and that 6 out of 7 of the cases with both HIF-1α and VEGF high coexpression showed distant metastasis. Here, HIF1A is linked to colonic neoplasm.