Results demonstrated that mean HIF-1α mRNA expression levels were 1.05 ± 0.58-fold in negative control group, 1.19 ± 0.52-fold in lymph node metastasis group, and 1.09 ± 0.32-fold in distant metastasis group. Here, HIF1A is linked to metastatic malignant neoplasm in the lymph nodes.