At the same time, there were statistically significant differences in high expression of these single molecules, and high expression of any two of the three molecules with regard to lymph node metastasis in patients with colon cancer (P = .028 for HIF-1α/CXCR4, P = .007 for HIF-1α/VEGF, and P = .004 for CXCR4/VEGF; Table 2). Here, CXCR4 is linked to metastatic malignant neoplasm in the lymph nodes.