In contrast, CXCR4 mRNA expression levels were significantly higher in lymph node metastasis group (15.91 ± 12.14 fold) and distant metastasis group (23.20 ± 14.84 fold) than in normal colonic tissue (6.23 ± 4.66 fold). Here, CXCR4 is linked to metastatic malignant neoplasm in the lymph nodes.