HIF-1α activation correlates with metastasis and can promote metastasis through the regulation of key factors governing tumor cell metastatic potential, including E-cadherin, lysyl oxidase (LOX), connective tissue growth factor (CTGF), and plasminogen activator inhibitor-1 (PAI-1), CXCR4 [23–27]. The gene discussed is CXCR4; the disease is neoplasm.