Moreover, experimental data show that there are statistically significant differences in high expression of single CXCR4 or VEGF molecules, and high expression of both CXCR4 and VEGF molecules with regard to distant metastasis in patients with colon cancer (P = .035 for CXCR4/VEGF; Table 2). This evidence concerns the gene VEGFA and malignant colon neoplasm.