In the present study of AMG 108 - a long-acting IL-1R inhibitor - improvements in the signs and symptoms of RA as measured by the ACR20 were greater in the 250 mg AMG 108 group (40.4%) at week 24, compared with the placebo group (29.1%; P = 0.022). This evidence concerns the gene IL1R1 and rheumatoid arthritis.