High CHD5 staining values were found to be significantly associated with INSS stages 1, 2, 3 (MYCN non-amplified) and 4s NB (n = 63), age at diagnosis <12 m (n = 63) and favorable tumor histology (n = 63); P < 0.001 for all the tested variables. The gene discussed is MYCN; the disease is neoplasm.