In this study, we show in vitro that both intracellular and extracellular Aβ production and the neuronal cell death associated with Aβ can be prevented by RARα signalling, and that there is induction of a disintegrin and metalloproteinase (ADAM)10, which has been shown to act as an α-secretase (Lammich et al., 1999; Endres et al., 2005), and whose modulation may be an opportunity for the treatment of AD (Endres & Fahrenholz, 2010). The gene discussed is RARA; the disease is Alzheimer disease.