On the basis of collective data on over 1,300 healthy population controls screened in our study and previously reported data (Bakrania, et al., 2008; Felder, et al., 2002; Suzuki, et al., 2009; Weber, et al., 2008) we identified three BMP4 mutations in our CRC cohort which are predicted to functionally deleterious on expressed BMP4 (none were identified in controls) would mean that there is more than a 90% probability that at least one of these variants contributes directly to the development of CRC. The gene discussed is BMP4; the disease is colorectal carcinoma.