PDZK1 and hepatocellular carcinoma: Finally, confocal analysis revealed extensive co-localization of non-tagged wildtype SR-BI with FLAG-tagged PDZK1 in the cytoplasm of transfected Huh-7 hepatoma cells (Figure 1D), with no apparent effect of mutation of PDZK1 on its localization or co-localization with SR-BI for each of the mutants S509A and S509D.