Infection of these cells with HCVcc (Jc1/Myc) and quantification of HCV-positive foci three days later revealed that overexpression of full-length PDZK1 significantly increased HCVcc infection levels in shRNA control cell lines and restored levels of HCVcc infection in PDZK1 shRNA#5-expressing cells to levels approaching those of the parental non-target shRNA control cells (Figure 5B). This evidence concerns the gene MYC and infection.