Given our observations that PDZK1 knockdown is associated with decreased HCV entry levels for both genotype 1a (HCVpp) and 2a (HCVcc) infection systems and the high degree of divergence between E1/E2 sequences for these genotypes, it is likely that the observed involvement of PDZK1 will hold true for all HCV genotypes. Here, PDZK1 is linked to infection.