PDZK1 and infection: Similarly infection of these cells with Jc1/GFP or Jc1/RFP infectious HCV chimeras, that bear the GFP- or RFP-coding sequences inserted in-frame into domain III of NS5A of the infectious genotype 2a chimera Jc1 [36], and flow cytometric analysis of GFP- or RFP-associated epifluorescence revealed that PDZK1-knockdown cells were approximately 80% (Jc1/GFP) and 60% (Jc1/RFP) less susceptible to infection with these chimeras than their control counterparts (Figures 3C and 3D).