In summary, our protein microarray analysis functionally links PD-associated LRRK2 to Ste20 kinases and RIP kinases, respectively, and identifies novel LRRK2 interactors/effectors (e.g. STK24, STK25, TAOK/MARKK, PKC zeta) that may contribute to its function in oxidative stress signaling and structural/functional plasticity in neurons. Here, PRKCZ is linked to Parkinson disease.