FADS1 and Eczematoid dermatitis: Separate analyses for both study populations revealed that in the LISA-study all SNPs of the FADS1 FADS2 gene cluster showed significant associations with the dichotomous outcome parental reported eczema in the first 2 years of life in both unadjusted and adjusted analyses, with ORs of about 2 and 4 for heterzygous and homozygous minor allele carriers, which is in good agreement with multiplicative increase of risks (confirmed by P-values for multiplicative trend between 0.003 and 0.005 without correction for multiple testing (see Supporting Information Table S7).