The odds for developing preeclampsia were significantly increased 2 to 3 fold for each 2-fold elevation in the concentration of sFlt1, sEng and the ratio of combined angiogenic factors (sFlt1+ sEng/PlGF) at study entry among women with multifetal gestations who later developed preeclampsia (Table 2). The gene discussed is PGF; the disease is preeclampsia.