It should be noted, though, that down regulation of sFRP-1 predisposes the mammary gland to tumorigenesis [98] while sFRP-2 is significantly downregulated in gastric cancer [99], and downregulation of both sFRP-1 and sFRP-2 contributes to cervical cancer progression [100]. The gene discussed is SFRP2; the disease is cervical carcinoma.