Other studies [60] combining primary cell cultures of rat juxtaglomerular cells, human tumor cell line (CaLu-6, [61]), renin enzymatic assay, and a variety of optical techniques provided important clues about the existence of a biomechanical coupling in renin-releasing cells (i.e., the so-called “intrarenal baroreceptor”, [92]). Here, REN is linked to neoplasm.