S100A12 did not fluctuate significantly when male (median: 69.5 ng/mL, range: 43.1-167.3 ng/mL) and female (median: 70.5 ng/mL, range: 42.6-123.8 ng/mL) IBD patients were compared (P = 0.729). This evidence concerns the gene S100A12 and irritable bowel syndrome.