No significant differences regarding S100A12 values were found betwen IBD subjects with (median: 63.9 ng/mL, range: 38.6-153.7 ng/mL) or without (median: 78.5 ng/mL, range: 51.6-156.9 ng/mL) extraintestinal manifestations (P = 0.293). Here, S100A12 is linked to irritable bowel syndrome.