Considering the smoking habits of subjects in the IBD group, although at first glance, higher S100A12 serum levels in UC non-smokers (median: 72.4 ng/mL, range: 47.6-152.6 ng/mL) compared to UC current smokers were observed, this difference did not reach statistical significance (P = 0.215). The gene discussed is S100A12; the disease is inflammatory bowel disease.