In both pooled cohorts, the HRneg/Tneg summation index proved prognostically superior to a recently described IR-7 gene signature derived from different HRneg training and validation cases, although expression of one gene in the HRneg/Tneg signature (CXCL13) appears to correlate with all components in the IR-7 signature, which, in turn, correlates strongly with other reported immune-related gene signatures and the extent of tumor infiltration by lymphocytes. This evidence concerns the gene CXCL13 and neoplasm.