This is consistent with observations among other HRneg outcome predictors (IR-7, STAT1, and IFN signatures) in which individual gene components are often more highly expressed in association with better prognosis [23-26], and this is in stark contrast with HRpos outcome predictors, in which elevated expression of the majority of gene components is associated with increased tumor proliferation and poor prognosis [22,23]. The gene discussed is IFNA1; the disease is neoplasm.