Compared to BE (GERD) without intraepithelial neoplasia or carcinoma (Figure 1a, Table 2), MMP-1 expression was significantly upregulated in BE (Figure 1a, Table 2) with adjacent EAC (Figure 1a, Table 2) and EAC without BE (Figure 1a, Table 2). This evidence concerns the gene MMP1 and gastroesophageal reflux disease.