MMP1 and Barrett esophagus: MMP-1 gene expression in BE (Median 3.6-fold difference compared to normal tissue; IQR 3.275 to 4.625-fold difference; n = 5) was significantly (p = 0.01) lower in comparison to EAC without BE (Median 7.9-fold difference compared to normal tissue; IQR 6.3 to 8.95-fold difference; n = 4; Figure 2b).