For example, anti-INF-γ autoantibodies are found in patients with susceptibility to non-tuberculosis mycobacterium infection [25-27], anti-IL-6 has been reported in a patient with chronic skin infection [28], and a variety of anti-cytokine autoantibodies are detected in a subset of thymoma patients with opportunistic infections [18,29,30]. This evidence concerns the gene IL6 and Opportunistic infection.