HLA-G and Renal insufficiency: The clinical diagnosis of Dent's disease is based on the presence of all three of the following criteria: (i) LMW proteinuria (elevation of urinary excretion of β2-microglobulin, Clara cell protein and/or RBP by at least 5-fold above the upper limit of normality); (ii) hypercalciuria (> 4 mg/kg in a 24 h-hour collection or > 0.25 mg Ca2+ per mg creatinine on a spot sample); and (iii) at least one of the following: nephrocalcinosis, kidney stones, hematuria, hypophosphataemia, or renal insufficiency.