CLCN5 and Dent disease: Thus, there is genetic heterogeneity for Dent's disease, with approximately 50-60% of patients having CLCN5 mutations (Dent disease 1), ~15% harbouring OCRL1 mutations (Dent disease 2) and the remaining 25-35% of patients having neither CLCN5 nor OCRL1 mutations but possibly defects in other genes.