Beyond, trans-resveratrol induced cell death in B-CLL cell lines in vitro as well as in ex vivo models, that was associated with typical apoptotic features like activation of caspase-3, loss of mitochondrial membrane potential and down-regulation of the two antiapoptotic proteins Bcl-2 and inducible nitric oxide synthase (iNOS) [84,85]. This evidence concerns the gene NOS2 and B-cell chronic lymphocytic leukemia.