SERPINE1 and Sepsis: We found an association between biomarker levels and sepsis severity (worst sepsis syndrome within 72 hours) for sFlt-1 (P < 0.001 for trend across groups), PAI-1 (P < 0.001), sE-selectin (P < 0.001), sICAM-1 (P < 0.05), and sVCAM-1 (P < 0.04) (Figure 2).