Three signaling pathways commonly used by these TFs were identified with the Functional Annotation Tool box from DAVID [29]: (1) the JNK/p38 MAPK signaling pathway, which involves Trp53, Nfkb1, and Fos as its down-stream targets, (2) the acute and (3) chronic myeloid leukemia pathways which contain Sfpi1, Stat5b and Rara. Here, SPI1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.