FADD and central nervous system cancer: To determine whether concurrent treatment of the therapeutic vectors, pG8-FasL and pG8-FADD, with TMZ or IR or both could induce an even greater extent of cell death, ΔGli36 glioma cells were pre-infected with MOI of 1.0 of pG8-FasL and pG8-FADD amplicon viruses, followed by treatment with TMZ, IR or both.