A fusion protein consisting of interleukin 13 (IL-13) and a mutated form of Pseudomonas exotoxin (IL-13-PE) has also been shown to induce potent and specific cytotoxicity in glioma cells that overexpresses the receptor for IL-13, IL13 receptor-α2 (IL13-Rα2) [50]. This evidence concerns the gene IL13RA2 and central nervous system cancer.