FADD and central nervous system cancer: As such, we explored whether the therapeutic efficacy of pG8-FasL could be improved in the presence of FADD. Our results showed that the co-expression of FasL and FADD in primary glioma cells enhanced apoptosis by 20% in vitro (Figure 2D) and prolonged the survival of intracranial glioma bearing mice (Figure 3A and 3B).