ZNF215 and Beckwith-Wiedemann syndrome: In humans, ZNF215 is preferentially expressed from the maternally inherited allele and maps to an imprinted gene cluster on human chromosome (HSA) 11p15.5, the genomic region associated with Beckwith-Wiedemann syndrome (BWS)--a genetic disorder characterised by a range of growth abnormalities, including gigantism [86].