Most of these SNPs are also linked to different cardiovascular traits, such as coronary artery disease, coronary artery calcification and atherosclerosis plaque areas, myocardial infarction, sudden cardiac death, stroke, as well as having phenotypic relationships with subclinical atherosclerotic traits such as carotid IMT (ESR1, APOB, PON1, USF1, ALOX5AP, ESR2, IL10, FCGR2A). The gene discussed is ESR1; the disease is Stroke.