TIMP3 and osteosclerosis: Furthermore, we show herein that over-expression of huTIMP-3 in hematopoietic cells in vivo 1) increases LSK cell proliferation, 2) favors myelopoiesis at the detriment of lymphopoiesis 3) increases trafficking of CFC to the spleen and 4) results in late onset fatal osteosclerosis whereby most of the BM cavity was filled with mineralized bone, demonstrating that TIMP-3 is a key regulator of both hematopoiesis and bone turn-over.