It is understood that no basement membranes exist under liver sinusoidal endothelial cells, thus liver cancer cells can not have the same adhesion to laminin or collagen as other tumor cells, and so it follows that integrin-mediated HCC metastasis and cell adhesion to FN play a decisive role in the formation of metastases [32-34]. The gene discussed is LAMB2; the disease is hepatocellular carcinoma.