Several reports have highlighted this type of application; for example, it has been found that arginine-glycine-aspartic acid (RGD) integrin-binding motif from FN containing the adhesion recognition signal Arg-Gly-Asp partially inhibit intrahepatic metastasis of murine hepatocellular carcinoma (HCC) [12]. Here, FN1 is linked to hepatocellular carcinoma.