PDGFB and central nervous system cancer: Notably, even if adult NG2-KO mice do not show any strong phenotype [13,32], it has been reported, though on the basis of a limited sample, that the lack of NG2 could be responsible for a reduction in the incidence of PDGF-B-induced tumors [33] indicating the possibility to disrupt NG2 activity as a way to treat gliomas.