For pancreatic cancer, conflicting roles of SERPINB5 have been described: Hong et al. showed SERPINB5-transfected PDAC cells to have reduced invasive ability [20] and Kashima et al. found SERPINB5 expression to increase with tumor progression from intraductal papillary mucinous neoplasm to non-invasive carcinomas but to decrease in invasive carcinomas [21]. Here, SERPINB5 is linked to pancreatic intraductal papillary-mucinous neoplasm.