A recent study comparing the expression levels of Hsc70 in different neuronal subtypes typically vulnerable in neurodegenerative diseases, including spinal motoneurons (vulnerable in amyotrophic lateral sclerosis (ALS)), neurons of the hippocampus/entorhinal cortices (vulnerable in Alzheimer’s disease (AD)), and tyrosine hydroxylase positive neurons of the substantia nigra (vulnerable in Parkinson’s disease (PD)), reported that the relative levels of Hsc70 expression was inversely correlated with the frequency of disease prevalence in the US population [107]. This evidence concerns the gene HSPA8 and early-onset autosomal dominant Alzheimer disease.