There are conflicting data regarding the importance of Fc-dependent functions of Th1-type cytophilic antibody subclasses (human IgG1 and IgG3; murine IgG2a and IgG2b) in protection against blood-stage malaria, and the impact of Th1 cytokines and IgG isotype on protective efficacy [50–53]. The gene discussed is IGHG3; the disease is malaria.