CXCL8 and Crohn disease: A link between TLR activation and angiogenesis has been observed in patients with Crohn's disease, where activation of TLRs located in gut myofibroblast results in an increased secretion of CXC chemokine ligand 8 (CXCL8), which is a potent angiogenetic factor implicated in the development of fibrosis [33,34].