An effect of agonistic anti-GITR on immune effector cells other than T cells was also observed by Zhou et al. They reported increased numbers and activation of T cells, but also of B cells and NK cells in draining lymph nodes of CT26 tumor-bearing BALB/c mice after DTA-1 treatment, and GITR stimulation enhanced PMA/Ionomycin-induced NK cell granule mobilization. This evidence concerns the gene TNFRSF18 and neoplasm.