In conclusion [32–34], obesity seems to alter the balance between TH1 and TH2 stimuli in fat, probably through depletion of TH2 cells and adipose tissue Treg cells, increase in CD8+ and TH1 cells, or a combination of both effects, leading to the infiltration of macrophages that promote inflammation. Here, CD8A is linked to obesity due to melanocortin 4 receptor deficiency.