IL18 and central nervous system cancer: Other drugs and proteins encapsulated in PLGA microspheres for the treatment of glioma include temozolomide [54], paclitaxel [55], imatinib mesylate for treating intracranial glioma xenografts [56], BCNU as an alternative for Gliadel [57], cisplatin [58], mitoxantrone [59] interleukin-18 [60] and 5-Fluorouracil [61,62].