This region delimited from centromere to telomere by TRPS1 and PVT1 contains MYC, two colorectal cancer risk loci, rs16892766 (8q23.3) [56] and rs6983267 (8q24.21), and one breast cancer risk locus rs13281615 (8q24.21) [57]. Here, TRPS1 is linked to breast cancer.