Type II diabetes is an endocrine dysfunction that is characterized by chronic hyperglycemia and decrease of insulin secretion or incapability of the peripheral tissues to respond to insulin and is usually associated with a loss of weight.[26]Animal models of non-insulin dependent diabetes (type II diabetes) could be produced after administering a single mild dose of STZ (40 mg/kg) in the adult rats.[19, 27]. The gene discussed is INS; the disease is type 2 diabetes mellitus.