Although MEK1-cDNA and CKS1B-shRNA doubly-transfected cells clearly showed increased cell death and growth inhibition compared with SCR-transfected control cells (Figure 5E & 5F, p < 0.05), these double-transfected cells exhibited significantly less cell death and growth inhibition than CKS1B-silenced myeloma cells (Figure 5E & 5F, p <0 .05), indicating that MEK1-transfection partially abrogated cell death and growth inhibition induced by CKS1B-knockdown. Here, MAP2K1 is linked to plasma cell myeloma.