The level of MCL1 was decreased in CKS1B silenced MM cells and increased in CKS1B over-expressing MM cells (Figure 3B & 3C); whereas MCL1 expression did not show alteration in MM cells manipulated by inhibition of SKP2 and over-expression of p27Kip1 (Figure 3D & 3E). The gene discussed is SKP2; the disease is Miyoshi myopathy.