SKP2 and Miyoshi myopathy: Interestingly, besides influencing cell growth and survival through regulation of p27Kip1, silencing of CKS1B also induces cell death and inhibits growth in MM cells in the presence of a bi-allelic deletion of the CDKN1B (p27Kip1) locus, indicating that CKS1B mediates its effects on cell growth and survival also through mechanisms that are independent p27Kip1 and SKP2 [4].