Nifuroxazide treatment decreased p-STAT3 in both EV- and CKS1B-transfected myeloma cells compared with untreated controls by western blot (Figure 4A), and it did not alter the total protein and phosphorylation of MEK/ERK1 (data not shown), confirming its specificity. This evidence concerns the gene MAPK3 and plasma cell myeloma.