Rather, the majority of evidence from previous studies suggests that these seven SNPs alter T2D susceptibility through effects on insulin sensitivity (rs1801282 [45]) or pancreatic beta cell function (rs5219, rs7903146, rs10946398, rs4402960, rs13266634 and rs1111875 [34,36,38,46-52]). Here, INS is linked to type 2 diabetes mellitus.