Using the Oncomine database we investigated changes in expression patterns for these methylated targets, and we found a significant association between progression of prostate cancer and metastasis with expression of a number of genes including G protein, beta-1 subunit (Gnb1), retinoblastoma binding protein 8 (rbbp8), secretogranin III (Scg3) and Sox1 (Figure 2). This evidence concerns the gene GNB1 and Familial prostate cancer.