TNF and myeloid sarcoma: Besides, 15d-PGJ2 is also effective in inhibiting production of cytotoxic molecules, including nitric oxide (NO), TNFα and interleukin 12, by microglial cells stimulated with interferon (IFN) γ and TNFα, molecules that have been implicated in pathogenesis of EAE and MS [28], by means of mechanisms that are PPARγ-independent.