Furthermore, the total frequency of IL-22-positive CD4 T cells was not significantly elevated in RA PBMC (1.09% (0.24 to 4.19)) and SFMC (1.12% (0.40 to 2.03)) compared with PBMC of healthy controls (0.87% (0.45 to 1.32)) (Figure 3C). This evidence concerns the gene IL22 and rheumatoid arthritis.