There was a non-significant trend towards a higher frequency of total CD4 T cells expressing IL-23R in RA SFMC (6.28% (3.63 to 9.07)) and RA PBMC (3.65% (2.07 to 5.31)) compared with the PBMC of healthy controls (2.38% (1.68 to 4.74)) (Figure 3F). This evidence concerns the gene CD4 and rheumatoid arthritis.