However, in a study included 109 patients with gastric adenocarcinomas who underwent a radical gastrectomy [31], Murayama et al. found neither cytoplasmic p-mTOR nor nuclear p-mTOR was independent prognostic factor, although they identified cytoplasmic p-mTOR expression was associated with poorer survival and correlated with the depth of tumour invasion, lymph nodes and tumour stage. This evidence concerns the gene MTOR and gastric adenocarcinoma.