LIMS1 and cancer: To evaluate whether the prosurvival function of PINCH1 in radiation cell survival depends on cell adhesion or is also conserved in suspension, we examined the clonogenic survival and expression and phosphorylation of a selected panel of prosurvival proteins in PINCH1fl/fl and PINCH1−/− mouse embryonic fibroblasts and human cancer cell lines grown either adherently or in suspension.