Taking all the ethnic groups as a whole, lower levels of HLA-B*35 (2.5 fold decrease, P = 0.078, 0R = 2.69, 95% CI = 0.90–8.03) allele was noted in DF patients while two other alleles (HLA-B*18 : 5.3 fold decrease, P = 0.017, Pc = 0.408 and B*58 : 2.68 fold decrease, P = 0.126, 0R = 2.83, 95% CI = 0.80–10.01) were noted to decrease in DHF patients as compared to controls. The gene discussed is HLA-B; the disease is Dengue hemorrhagic fever.