HLA-B and dengue disease: Taking the total dengue cases in all the three ethnic groups, we noticed increased frequencies of HLA-B* 78 (2.4 fold rise, P = 0.09) allele in DF patients when compared to healthy controls while in the DHF group HLA-B*53 increased 2.9 fold (P = 0.042, Pc = 1.008) as compared to healthy individuals.