For the HLA-B allele group (Table 5 and 6), distinctively in the Malay patients, decreased frequencies of alleles HLA-B*18 (12.5 fold decrease, P = 0.101 in DF; 12.5 fold decrease, P = 0.024, Pc = 0.576 in DHF), B*35 (4.4 fold decrease, P = 0.163, OR = 5, 95% CI = 0.61–41.1 in DF; 2.9 fold decrease, P = 0.202, 0R = 3.33, 95% CI = 0.69–16.11 in DHF) and B*39 (3.1 fold decrease, P = 1 in DF; 3.1 fold decrease, P = 0.528 in DHF) were observed both in DF and DHF patients. Here, HLA-B is linked to Dengue hemorrhagic fever.