In the Chinese DF patients, HLA-B*15 increased 2.7 fold (P = 0.084, 0R = 0.31, 95% CI = 0.09–1.12), B*18 increased 2.3 fold (P = 0.518, 0R = 0.43, 95% CI = 0.03–7.11) and B*78 increased 3.6 fold (P = 0.304) while in the Chinese DHF patients rising frequencies of HLA-B*07, B*14 (2.0 fold rise, P = 1, 0R = 0.49, 95% CI = 0.030–8.13), B*27 (4.0 fold rise, P = 0.257, 0R = 0.24, 95% CI = 0.02–2.73), B*37, B*53, B*56 (6.3 fold rise, P = 0.109) and B*52 (3.1 fold rise, P = 0.333) alleles were noted as compared to healthy individuals. The gene discussed is HLA-B; the disease is dengue disease.