SELE and neoplasm: As opposed to the binding to the tumor associated vessels, ESTA-1 binding was almost absent in the normal human tissues, including the adrenal, brain, temporal lobe, breast, cervix, heart, kidney, liver, lung, pancreas, placenta, salivary gland, skeletal muscle, small intestine, spleen, stomach, thyroid, and uterus, with the exception of minor binding to the vessels of the skin (data not shown), where E-selectin is constitutively expressed [35].