Personal or family history of atopy is another association.[6] From 30 to 75% of patients with Netherton's syndrome develop atopic manifestations such as atopic dermatitis-like skin lesions, urticaria, angioneurotic edema, asthma, allergic rhinitis, food allergy, peripheral eosinophilia and elevated serum IgE level. The gene discussed is IGHE; the disease is allergic rhinitis.