Methylated genes in cluster 1 include proteins highly expressed in neural systems (CHGA, GABRB3, GAS7, FEV), strongly related to leukemia (TCL1A, FLT3, FLT4), involved in cell growth and proliferation (EGFR, WT1, SMO, IGF2, RET), and transcription factors involved in diverse or unknown functions (PAX3, PAX7, HOXC13, ZIM2). The gene discussed is PAX3; the disease is leukemia.