Among the 6 genes where mutations occur in at least 10 cell lines, we found strong negative associations of frame-shift mutations and expressions on tumor suppressors TP53 (log likelihood ratio 8.28, p-value < 0.05), CDKN2A (log likelihood ratio 5.43, p-value < 10-3) and PTEN (log likelihood ratio 10.75, p-value < 3 × 10-4). The gene discussed is TP53; the disease is neoplasm.