TLE5 and neoplasm: In addition to its role in osteogenesis, Runx2, a TF positively or negatively modulated by GRG5 or long TLE/GRGs (Thirunavukkarasu et al., 1998; Wang et al., 2004; Gasperowicz and Otto, 2005), functions as a potent tumor suppressor (Baniwal et al., 2009).