ANGPT2 and colorectal carcinoma: Differences in survival remained significant when patients with primary and relapsed CRC were analysed separately (Supplementary Table 3), and in a multivariate analysis of variables with potential impact on OR, PFS and OS (gender, age, site, treatment regimen and treatment line), serum Ang-2 was confirmed as an independent prognostic marker for all three end points (P=0.003, P=0.005 and P=0.003, respectively).