Pre-therapeutic serum Ang-2 concentrations in CRC patients ranged from 0.7 to 12.1 ng ml−1 (median: 3.5 ng ml−1) and did not correlate with other vascular markers such as serum levels of VEGF (median: 0.19 ng ml−1), tumour MVD (median: 42 per HPF) or PC (median: 52%). The gene discussed is VEGFA; the disease is neoplasm.