Although these findings are at odds with previous immunohistochemical studies reporting Ang-2 expression in the tumour cell compartment of CRC (Ochiumi et al, 2004; Ogawa et al, 2004; Chung et al, 2006; Gu et al, 2006), the published immunohistochemical data should be interpreted with caution owing to the limited specificity of the available antibodies. The gene discussed is ANGPT2; the disease is neoplasm.