In a previous study, however, Shimizu et al. [37] found no significant association between the LIPG 584C > T polymorphism and HDL-C levels, but multivariate regression analyses showed that the association of the LIPG 584T allele with acute myocardial infarction was statistically significant and independent of other risk factors when age, sex, hypertension, hypercholesterolemia, and diabetes mellitus were included in the analyses. This evidence concerns the gene LIPG and familial hypercholesterolemia.