VEGFA and gastrointestinal stromal tumor: In addition to the VEGF-A neutralizing antibody, which is already a standard treatment for late-stage colorectal cancer in the USA [7], sorafenib was recently approved by the US Food and Drug Administration for the treatment of renal and hepatic cancers, and sunitinib was approved for the treatment of gastrointestinal stromal tumor (GIST) and renal cell carcinoma.